Study 1: The resveratrol-containing gel reduces acne in human subjects
A pilot study evaluated the effect of the resveratrol containing gel on the acne vulgaris in 20 subjects with acne. The subjects were guided to apply resveratrol-containing hydrogel on the face for 60 days. The application of the gel resulted in a 53.75% mean reduction of acne and 66.7% mean reduction in the average area of microcomedones. The study demonstrated the anti-acne potential of resveratrol in human subjects.
Fabbrocini G, Staibano S, De Rosa G, Battimiello V, Fardella N, Ilardi G, La Rotonda MI, Longobardi A, Mazzella M, Siano M, Pastore F, De Vita V, Vecchione ML, Ayala F. Resveratrol-containing gel for the treatment of acne vulgaris: a single-blind, vehicle-controlled, pilot study. Am J Clin Dermatol. 2011;12(2):133-144.
Study 2: Resveratrol enhances the antioxidant activity and skin parameters of the formula containing cyclodextrin
A study evaluated the effect of a cream containing trans-resveratrol, and β-cyclodextrin on different skin parameters such as corneometry, colorimetry, and elastometry in human volunteers. The study was carried out in eight women (age between 45 and 70 with) clear clinical signs of photoaging viz., loss of luminosity, hydration, and elasticity. The inclusion of the resveratrol improved the antioxidant capability of the cyclodextrin formulation. The topical application of the formula containing resveratrol and cyclodextrin showed a visible improvement of clinical conditions i.e., skin hydration, complexion, and elasticity with a remarkable decrease of aging signs.
Moyano-Mendez JR, Fabbrocini G, De Stefano D, Mazzella C, Mayol L, Scognamiglio I, Carnuccio R, Ayala F, La Rotonda MI, De Rosa G. Enhanced antioxidant effect of trans-resveratrol: potential of binary systems with polyethylene glycol and cyclodextrin. Drug Dev Ind Pharm. 2014;40(10):1300-1307.